Description

2,5-Difluorobenzylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in fine chemical synthesis. Its primary value lies in its ability to introduce the 2,5-difluorobenzyl moiety into target molecules, enabling the construction of complex fluorinated intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key building block for active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic structures for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorobenzyl group imparts specific biological activity and environmental persistence profiles.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and organic electronic materials to modify electronic properties and stability.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed cross-coupling reactions (e.g., Kumada coupling) to form new carbon-carbon bonds in complex molecule assembly.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides to create new chiral centers and extend carbon chains.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and scale-up projects requiring specialized fluorinated organometallic chemistry.

Basic Information

Product Name	2,5-Difluorobenzylmagnesium Bromide
CAS No.	522651-57-6
Molecular Formula	C7H5BrF2Mg
Molecular Weight	223.32 g/mol
Synonyms	(2,5-Difluorophenyl)methylmagnesium bromide; 2,5-Difluorobenzylmagnesium bromide solution; Magnesium, bromo(2,5-difluorophenyl)methyl-; 2,5-Difluorobenzyl Grignard reagent; (2,5-Difluorobenzyl)magnesium bromide; 1-(Bromomagnesio)methyl-2,5-difluorobenzene; α-Bromo-2,5-difluorotoluene magnesium complex
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluorobenzylmagnesium Bromide is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, active Grignard content, and impurity profile. Our quality commitment ensures consistency and reliability for your critical synthetic steps, supporting cGMP and ISO 9001 standards where required.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, maintain storage at recommended temperatures (typically 2-8°C or as specified) and ensure containers are properly sealed to prevent exposure to air and moisture, which can deactivate the reagent.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (Active Grignard)	≥ 95% (by Titration)
Identification (IR / NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.