Description

3-Cyano-4-Fluorophenylzinc Bromide is a highly reactive organozinc reagent, specifically a functionalized arylzinc halide, essential for advanced organic synthesis. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, to introduce the valuable 3-cyano-4-fluorophenyl moiety into complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 3-cyano-4-fluorophenyl group into potential drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Active Ingredient Development: Used in the research and production of novel herbicides and fungicides that require this specific aromatic substitution pattern.
• Cross-Coupling Reactions: Primarily employed in Negishi coupling with various aryl, heteroaryl, or vinyl halides to form biaryl structures under mild conditions.
• Ligand and Material Science: Serves as a precursor for creating specialized ligands for catalysis or functional monomers for advanced polymers and electronic materials.
• Process Chemistry & Scale-Up: Suitable for transitioning from laboratory-scale discovery to pilot plant production of target molecules, offering a reliable and selective coupling pathway.

Basic Information

Item	Details
Product Name	3-Cyano-4-Fluorophenylzinc Bromide
CAS No.	518990-00-6
Molecular Formula	C7H3BrFNNZn
Molecular Weight	Contact for details
Synonyms	(3-Cyano-4-fluorophenyl)zinc bromide; Zinc, bromo(3-cyano-4-fluorophenyl)-; 4-Fluoro-3-cyanophenylzinc bromide; 3-Cyano-4-fluorobenzenezinc bromide; Arylzinc bromide reagent; Organozinc reagent CAS 518990-00-6
EINECS	Contact for details

Quality Control

Every batch of 3-Cyano-4-Fluorophenylzinc Bromide is manufactured and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our standard quality commitment includes verification of reactivity and concentration, typically provided as a solution in tetrahydrofuran. A comprehensive Certificate of Analysis (COA) detailing batch-specific data is available for all shipments, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is easily oxidized (store under inert atmosphere) and highly volatile. For optimal stability and safety, store the sealed reagent bottle under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (Typical, other concentrations available)
Assay (Titration)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.