Description

3-Chloro-4-Methylphenylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to act as a powerful nucleophile, enabling the efficient introduction of the 3-chloro-4-methylphenyl moiety into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing key intermediates in active ingredient development.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex molecules in the research and development of new active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the chloromethylphenyl group is a critical structural component.
• Ligand and Catalyst Preparation: Serves as a precursor for specialized ligands used in asymmetric catalysis and transition metal complexes.
• Advanced Material Development: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Fine Chemical Production: Facilitates the production of specialty chemicals, dyes, and pigments requiring specific aryl group functionalization.
• Cross-Coupling Reactions: Acts as a crucial reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	3-Chloro-4-Methylphenylmagnesium Bromide
CAS No.	515158-85-7
Molecular Formula	C7H6BrClMg
Molecular Weight	229.78 g/mol
Synonyms	3-Chloro-4-methylphenylmagnesium bromide; (3-Chloro-4-methylphenyl)magnesium bromide; 3-Chloro-p-tolylmagnesium bromide; Magnesium, bromo(3-chloro-4-methylphenyl)-; Grignard reagent, 3-chloro-4-methylphenylmagnesium bromide; 3-Chloro-4-methylbenzylmagnesium bromide (common misnomer); 3-Chloro-4-methylphenyl Grignard reagent; 3-Chloro-4-methylphenylmagnesium bromide solution
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Methylphenylmagnesium Bromide is manufactured under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent composition. A comprehensive Certificate of Analysis (COA) detailing concentration, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, store at 2-8°C under inert gas. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown
Concentration (in THF or Ether)	0.5 M - 2.0 M (Typical)
Assay (by Titration)	≥ 95% (of stated concentration)
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.