Description

Neothramycin B CAS NO 59593-15-6 is an anthracycline antibiotic compound known for its potent biological activity. This product is valued in research and development for its role as a biochemical tool in studying DNA intercalation and topoisomerase inhibition. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research and novel therapeutic discovery.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anticancer agents.
• Biochemical Studies: Used as a precise molecular probe to investigate mechanisms of DNA binding, intercalation, and the inhibition of topoisomerase II activity.
• Antibiotic Mechanism Research: Employed in microbiological and pharmacological studies to understand the structure-activity relationships of anthracycline antibiotics.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in chemical biology, medicinal chemistry, and molecular pharmacology.
• Standards & Calibration: Acts as a high-purity analytical standard for quality control and method validation in HPLC and LC-MS assays within pharmaceutical QC laboratories.

Basic Information

Product Name	Neothramycin B
CAS No.	59593-15-6
Molecular Formula	C21H19NO9
Molecular Weight	429.38 g/mol
Synonyms	Neothramycin B; Antibiotic MA 144 B1; 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-ε-rhodomycinone; (7S,9S)-9-Acetyl-7-[(2,6-dideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-4-methoxy-5,12-naphthacenedione; MA 144 B1; ε-Rhodomycinone 7-α-L-amicetoside
EINECS	Contact for details

Quality Control

Our Neothramycin B is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets the stringent requirements for research-grade materials. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.