Description

Poly(2-Aminoadenylic Acid)-Poly U is a synthetic, double-stranded RNA complex formed by the hybridization of poly(2-aminoadenylic acid) with polyuridylic acid. This compound is a critical research-grade nucleic acid polymer, primarily valued for its role in studying RNA structure, function, and protein synthesis mechanisms. It is essential for molecular biology and biochemistry laboratories engaged in fundamental research on translation, nucleic acid hybridization, and the development of novel therapeutic platforms.

Application

• Molecular Biology Research: Used as a model system for studying RNA-RNA interactions, duplex stability, and hybridization kinetics.
• Biochemical Assays: Serves as a substrate or template in in vitro translation systems to investigate protein synthesis and ribosome function.
• Therapeutic Development: Acts as a research tool in the exploration of nucleic acid-based therapies, including antisense and RNA interference mechanisms.
• Diagnostic Probe Development: Utilized in the design and validation of diagnostic assays that rely on specific nucleic acid pairing.
• Enzymology Studies: Employed to study the activity and specificity of enzymes such as nucleases, polymerases, and helicases that act on double-stranded RNA.
• Academic & Pharmaceutical R&D: A key reagent for universities, research institutes, and pharmaceutical companies conducting basic and applied life science research.

Basic Information

Product Name	Poly(2-Aminoadenylic Acid)-Poly U
CAS No.	58382-91-5
Molecular Formula	(C10H12N6O6P)n • (C9H11N2O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(2-NH2A)-Poly U; Poly(2-Aminoadenylic Acid)-Polyuridylic Acid Complex; 2-Aminoadenylic Acid Polymer Complex with Poly U; Poly(2-Amino-A)-Poly U; Poly(2-NH2-A)-Poly(U); dsRNA [Poly(2-NH2A):Poly(U)]; Poly(2-Aminoadenylic Acid) • Polyuridylic Acid Salt
EINECS	Contact for details

Quality Control

Our research-grade nucleic acid polymers are produced and tested under stringent conditions to ensure batch-to-batch consistency and performance. Each lot is characterized for identity, purity, and hybridization integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as absorbance ratios (A260/A280), melting temperature (Tm), and confirmation of duplex formation. We adhere to rigorous internal quality standards suitable for critical life science research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized solid or powder
Identification (UV-Vis)	Characteristic absorption spectrum for polynucleotide complex
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95% (as duplex complex)
Absorbance Ratio (A260/A280)	1.8 - 2.0 (in suitable buffer)
Hybridization State	Confirmed double-stranded (dsRNA) by melting curve analysis
Solubility	Soluble in sterile nuclease-free water or TE buffer
Biological Activity	Functional in in vitro translation assay (as reported)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.