Description

Poly(Da-Dc).Poly(Dg-Dt) is a synthetic, double-stranded DNA polymer with a defined alternating sequence of deoxyadenosine-deoxycytidine and deoxyguanosine-deoxythymidine nucleotides. This compound is a critical research-grade material for studying nucleic acid structure, protein-DNA interactions, and the fundamental mechanisms of molecular biology. It serves as a vital tool for scientists and developers in the fields of biochemical research, diagnostic assay development, and pharmaceutical discovery, providing a standardized substrate for enzymatic studies and biophysical analyses.

Application

• Biochemical Research: Used as a defined-sequence substrate for studying DNA polymerases, nucleases, helicases, and other DNA-modifying enzymes.
• Biophysical Studies: Essential for investigating DNA duplex stability, hybridization kinetics, and ligand-DNA binding interactions using techniques like calorimetry and spectroscopy.
• Diagnostic Development: Serves as a control or calibrator in the development of PCR-based assays, hybridization probes, and next-generation sequencing platforms.
• Pharmaceutical Screening: Employed in high-throughput screening assays to identify novel compounds that interact with specific DNA sequences or structures.
• Academic & Institutional Use: A fundamental reagent for university and institutional laboratories conducting advanced research in genetics, molecular biology, and biophysics.

Basic Information

Product Name	Poly(Da-Dc).Poly(Dg-Dt)
CAS No.	57683-27-9
Molecular Formula	(C10H14N5O6P • C9H14N3O7P)n • (C10H14N5O7P • C10H15N2O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dA-dC)-Poly(dG-dT); Poly(deoxyadenylic-deoxycytidylic acid)-Poly(deoxyguanylic-deoxythymidylic acid); Poly(dA-dC):Poly(dG-dT); Alternating dA-dC / dG-dT Copolymer; Synthetic DNA Polymer; Poly(dA-dC).Poly(dG-dT) Sodium Salt; DNA Duplex (dA-dC:dG-dT); Research-Grade DNA Polymer
EINECS	Contact for details

Quality Control

Our Poly(Da-Dc).Poly(Dg-Dt) is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes rigorous quality testing, including assessment of sequence integrity, duplex formation, and absence of nucleases. A comprehensive Certificate of Analysis (COA) detailing purity, concentration (OD260), and physical state is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For extended use, prepare aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized solid or solution
Identification (UV-Vis)	Characteristic absorbance profile with A260/A280 ratio typical for double-stranded DNA
Assay (Purity, HPLC)	≥ 95% (as polymeric duplex)
Sequence Integrity	Confirms alternating dA-dC / dG-dT pattern
Duplex Formation (Melting Temp, Tm)	Reported value provided per batch
Endotoxin Level (LAL)	< 10 EU/mg (if specified for sensitive applications)
Nuclease Activity	Not detected

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.