Description

Poly(Thymidylyl-(5'-3')-2-Amino-2-Deoxy-5'-Adenylic Acid) is a specialized dinucleotide analog, a key building block in oligonucleotide synthesis and biochemical research. This compound is critical for studying nucleic acid interactions, enzyme mechanisms, and for the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on molecular biology, antisense technology, and nucleotide-based drug discovery.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite or solid-phase synthesis intermediate for creating custom DNA/RNA sequences and analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate polymerase, nuclease, and ligase activities.
• Antisense & Therapeutic Development: A foundational component in the research and development of antisense oligonucleotides and other nucleotide-based therapeutics.
• Diagnostic Probe Development: Employed in the design and synthesis of labeled probes for hybridization assays and molecular diagnostics.
• Structural Biology Studies: Utilized in NMR and X-ray crystallography to understand nucleic acid structure, stability, and ligand binding.
• Enzyme Mechanism Analysis: Acts as a tool compound to elucidate the catalytic pathways and specificity of nucleic acid-processing enzymes.

Basic Information

Product Name	Poly(Thymidylyl-(5'-3')-2-Amino-2-Deoxy-5'-Adenylic Acid)
CAS No.	55711-20-1
Molecular Formula	C20H25N7O12P2
Molecular Weight	617.40 g/mol
Synonyms	d(TpA); Thymidylyl(3'→5')-2'-deoxy-2'-aminoadenylic acid; Tp(dA); 2'-Amino-2'-deoxyadenylyl-(3'→5')-thymidine; Dinucleotide T-A analog; 2'-NH2-dA-thymidine dinucleotide; pd(T-A) analog; Oligonucleotide intermediate 55711-20-1
EINECS	Contact for details

Quality Control

Our Poly(Thymidylyl-(5'-3')-2-Amino-2-Deoxy-5'-Adenylic Acid) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive research and development applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.