Description

Chloro(p-Chlorophenyl)Magnesium is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to act as a nucleophile, introducing the p-chlorophenyl group into target molecules with high precision and efficiency. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing active pharmaceutical ingredients (APIs), novel crop protection agents, and specialty chemical intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for constructing complex molecules in the development of new active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific chlorinated aromatic structures.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials, including liquid crystals and electronic chemicals.
• Fine Chemical Production: Integral in multi-step synthetic routes for high-value specialty chemicals and flavors & fragrances.
• Cross-Coupling Reactions: A crucial reagent in Kumada and other transition-metal-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	Chloro(p-Chlorophenyl)Magnesium
CAS No.	51833-36-4
Molecular Formula	C6H4Cl2Mg
Molecular Weight	167.30 g/mol
Synonyms	(4-Chlorophenyl)magnesium chloride; p-Chlorophenylmagnesium chloride; 1-Chloro-4-(chloromagnesio)benzene; 4-Chlorophenylmagnesium Chloride; Grignard Reagent (p-ClC6H4MgCl); Magnesium, chloro(4-chlorophenyl)-; (p-Chlorophenyl)magnesium chloride
EINECS	Contact for details

Quality Control

Our Chloro(p-Chlorophenyl)Magnesium is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profile. Our quality systems are designed to meet the exacting standards of cGMP and ISO environments where traceability and purity are paramount.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this material must be stored under an inert atmosphere (argon or nitrogen) at temperatures between 2°C and 8°C. The container should be kept in a cool, dry, well-ventilated area away from sources of ignition, moisture, and incompatible materials such as acids, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration	Typically 0.5M - 2.0M in THF or Diethyl Ether
Assay (Titration)	≥ 95% (as Grignard reagent)
Identification (IR)	Conforms to structure
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.