Description

Poly 8-Bromoadenylic Acid is a chemically modified polynucleotide derivative where the adenine base is brominated at the 8-position. This specific halogenation is crucial for altering the electronic properties and base-pairing behavior of the nucleic acid, making it a valuable tool in structural and biochemical research. It is primarily utilized by researchers in molecular biology, biochemistry, and pharmaceutical development for probing nucleic acid structure, function, and interactions.

Application

• Biochemical Research Probe: Used to study nucleic acid conformation, stability, and the effects of base modification on duplex formation.
• Enzyme Interaction Studies: Serves as a substrate or inhibitor to investigate the specificity and mechanism of nucleases, polymerases, and other nucleic acid-processing enzymes.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of nucleic acids and their complexes with proteins.
• Antisense & Therapeutic Development: Investigated for the development of modified oligonucleotides with potential therapeutic applications, leveraging its altered base-pairing properties.
• Photochemical & Cross-linking Studies: The bromine atom can facilitate specific photochemical reactions for cross-linking experiments to map biomolecular interactions.
• Material Science for Nucleic Acids: Exploration of modified polynucleotides for creating novel biomaterials or nano-structures with unique electronic properties.

Basic Information

Product Name	Poly 8-Bromoadenylic Acid
CAS No.	50828-34-7
Molecular Formula	(C10H11BrN5O6P)n
Molecular Weight	Contact for details (Polymeric)
Synonyms	Poly(8-Bromoadenylic acid); Poly(8-BrA); 8-Bromoadenylic Acid Homopolymer; 8-Bromo-poly(A); Poly(8-bromoadenylate); Poly(8-Br-adenylic acid); Brominated Polyadenylic Acid
EINECS	Contact for details

Quality Control

Our Poly 8-Bromoadenylic Acid is produced and tested under stringent quality management protocols. Each batch is characterized to ensure consistency in chain length, degree of bromination, and purity. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as UV absorbance profile, HPLC purity, and confirmation of structure. We support research and development with material that meets the exacting standards required for reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (UV-Vis)	Characteristic spectrum of brominated adenine
Identification (HPLC)	Retention time consistent with reference
Purity (HPLC)	≥ 95% (Polymeric fraction)
Extinction Coefficient (ε260)	Contact for details
Degree of Bromination	Contact for details
Average Chain Length (n)	Contact for details
Solubility	Soluble in aqueous buffers, DMSO
Water Content (KF)	< 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.