Description

2-Thienylmagnesium Bromide Solution is a versatile organometallic reagent, specifically a Grignard reagent, widely used for the formation of carbon-carbon bonds in complex organic synthesis. Its primary value lies in its ability to introduce the 2-thienyl group into target molecules, a key structural motif in the development of advanced materials and active pharmaceutical ingredients (APIs). This solution is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with specific electronic or biological properties.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing heterocyclic thiophene rings for drug discovery and development.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the thienyl moiety imparts specific biological activity.
• Material Science & Organic Electronics: Crucial for constructing π-conjugated systems in the manufacture of organic semiconductors, OLEDs (Organic Light-Emitting Diodes), and conductive polymers.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Industrial R&D: A fundamental tool for research chemists in universities and corporate labs exploring new synthetic methodologies and novel molecular architectures.

Basic Information

Product Name	2-Thienylmagnesium Bromide Solution
CAS No.	5713-61-1
Molecular Formula	C4H3BrMgS
Molecular Weight	187.33 g/mol
Synonyms	Thiophen-2-ylmagnesium bromide; 2-Thienylmagnesium bromide; 2-Thiophenylmagnesium bromide; Magnesium, bromo(2-thienyl)-; 2-Thienyl Grignard reagent; 2-Thienylmagnesium bromide solution in THF/toluene/ether; α-Thienylmagnesium bromide
EINECS	227-172-6

Quality Control

Every batch of our 2-Thienylmagnesium Bromide Solution is manufactured and tested under stringent quality management systems to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as concentration (typically 0.5M to 1.0M in THF or other ether solvents), assay by titration, and impurity profiles. Our quality commitment ensures the reagent meets the high-purity standards required for sensitive pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, this solution must be stored under a dry, inert gas (argon or nitrogen) atmosphere at recommended temperatures of 2°C to 8°C. Keep the container tightly sealed in a cool, well-ventilated place, away from heat, sparks, and open flames. Use appropriate precautions for pyrophoric materials.

Specification

Item	Specification
Appearance	Clear, colorless to light brown or gray solution
Concentration	0.5 M in Tetrahydrofuran (typical, other solvents available)
Assay (Titration)	≥ 95% (as C4H3BrMgS)
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.