Description

3-Fluoro-2-Methylphenylmagnesium Chloride is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for constructing complex molecular frameworks. Its core value lies in introducing the versatile 3-fluoro-2-methylphenyl moiety into target molecules, enabling the synthesis of advanced intermediates for pharmaceuticals and agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for creating novel fluorinated compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) with fluorinated aromatic rings, enhancing metabolic stability and bioavailability.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the fluoro-methylphenyl group imparts specific biological activity.
• Material Science Research: Employed in the preparation of specialty polymers and liquid crystals, where fluorine atoms modify material properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: Serves as a nucleophile in palladium-catalyzed reactions (e.g., Kumada coupling) for carbon-carbon bond formation.
• Nucleophilic Addition to Carbonyls: Fundamental reagent for adding the aryl group to aldehydes, ketones, esters, and other electrophiles in laboratory and pilot-scale synthesis.
• Fine Chemical Production: Critical for the custom synthesis of complex, high-value fluorinated organic molecules for various industrial applications.

Basic Information

Product Name	3-Fluoro-2-Methylphenylmagnesium Chloride
CAS No.	480424-74-6
Molecular Formula	C7H6ClFMg
Molecular Weight	168.88 g/mol
Synonyms	(3-Fluoro-2-methylphenyl)magnesium chloride; 2-Methyl-3-fluorophenylmagnesium chloride; Magnesium, chloro(3-fluoro-2-methylphenyl)-; 3-Fluoro-o-tolylmagnesium chloride; Grignard reagent 3-Fluoro-2-methylphenyl; 480424-74-6; (3-Fluoro-2-methylphenyl)magnesium chloride solution
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Methylphenylmagnesium Chloride is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing concentration, titration assay, and solvent specifications. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the exacting standards of the pharmaceutical and advanced chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. The solution is highly volatile, moisture-sensitive, and easily oxidized. Keep away from heat, sparks, open flames, and strong oxidizers. Use only in a well-ventilated area with appropriate safety equipment.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Typical)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Solvent	Specified (Tetrahydrofuran, Diethyl ether, etc.)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.