Description

3-(R)-[1-(2-(S)-Benzyloxymethyl-Pyrrolidine-1-Carbonyl)-2-(S)-Methyl-Propylcarbamoyl)-Octanoic Acid n-Hydroxysuccinimidyl Ester is a specialized, high-purity active pharmaceutical intermediate (API) and a key building block in advanced organic synthesis. This compound is critically important for its role as a reactive ester, facilitating efficient amide bond formation under mild conditions, which is essential for constructing complex peptide and peptidomimetic structures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and metabolic diseases.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of complex peptide-based drug candidates and protease inhibitors.
• Peptide Coupling Reagent: Utilized as an activated ester (NHS ester) for efficient, racemization-free amide bond formation in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: Used to label proteins, antibodies, or other biomolecules with probes, dyes, or drug molecules for diagnostic and therapeutic applications.
• Prodrug Synthesis: Serves as a key component in the design and synthesis of prodrugs to improve the bioavailability and targeting of active pharmaceutical ingredients.
• Chemical Biology Research: Employed in academic and industrial R&D for studying enzyme mechanisms and protein-protein interactions.
• Material Science: Potential use in creating functionalized polymers and surfaces with bioactive properties.

Basic Information

Product Name	3-(R)-[1-(2-(S)-Benzyloxymethyl-Pyrrolidine-1-Carbonyl)-2-(S)-Methyl-Propylcarbamoyl)-Octanoic Acid n-Hydroxysuccinimidyl Ester
CAS No.	460754-32-9
Molecular Formula	C30H43N3O6
Molecular Weight	541.68 g/mol
Synonyms	N-Hydroxysuccinimide Ester of 3-(R)-[1-(2-(S)-Benzyloxymethyl-Pyrrolidine-1-Carbonyl)-2-(S)-Methyl-Propylcarbamoyl)-Octanoic Acid; (R)-3-((S)-1-((S)-2-(Benzyloxymethyl)pyrrolidine-1-carbonyl)-2-methylpropylcarbamoyl)octanoic Acid N-Succinimidyl Ester; 460754-32-9; BOC Sciences Brand Name: BBL-400126; Advanced Peptide Coupling Reagent; NHS-Activated Ester Intermediate; Protease Inhibitor Precursor
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring traceability and consistency across all batches. Every lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dedicated, temperature-controlled freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.