Description

4-Chloro-3-Methylphenylmagnesium Bromide is a highly reactive Grignard reagent, a cornerstone intermediate in modern synthetic organic chemistry. Its value lies in its ability to form new carbon-carbon bonds, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable aryl coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing substituted biphenyl or diarylmethane cores.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require specific chlorinated and methylated aromatic structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Fine Chemical Production: Facilitates the introduction of the 4-chloro-3-methylphenyl group into complex molecules for flavors, fragrances, and dyes.
• Cross-Coupling Reactions: A vital reagent in Kumada, Negishi, and related palladium-catalyzed cross-coupling methodologies.

Basic Information

Product Name	4-Chloro-3-Methylphenylmagnesium Bromide
CAS No.	460747-53-9
Molecular Formula	C7H6ClMgBr
Molecular Weight	229.78 g/mol
Synonyms	(4-Chloro-3-methylphenyl)magnesium bromide; 1-Chloro-2-methyl-4-(bromomagnesio)benzene; 4-Chloro-m-tolylmagnesium bromide; 3-Methyl-4-chlorophenylmagnesium bromide; Grignard reagent, (4-chloro-3-methylphenyl)magnesium bromide; Magnesium, bromo(4-chloro-3-methylphenyl)-; (4-Chloro-3-methylphenyl)magnesium bromide solution
EINECS	Contact for details

Quality Control

Every batch of our 4-Chloro-3-Methylphenylmagnesium Bromide is manufactured and tested under stringent quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay by titration, and impurity profile. Our quality assurance protocols ensure consistency and reliability for your critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C in a dedicated, well-ventilated flammable storage area. Keep away from moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown solution
Concentration	0.5 M in THF or as specified
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.