Description

5-Chloro-2-Methoxyphenylmagnesium Bromide, 0.50M In 2-Methyltetrahydrofuran is a high-purity Grignard reagent solution, essential for introducing the 5-chloro-2-methoxyphenyl moiety in complex organic syntheses. This product offers a reliable and consistent source of the organometallic species, enabling efficient carbon-carbon bond formation critical for advanced chemical manufacturing. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing key molecular frameworks.

Application

• As a key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• For the preparation of advanced intermediates in agrochemical and crop protection agent development.
• In the research and production of specialty chemicals and functional materials, such as liquid crystals and OLED materials.
• For coupling reactions, including Kumada and Negishi cross-couplings, to form biaryl structures.
• As a nucleophile in addition reactions to carbonyl compounds (aldehydes, ketones, esters) and other electrophiles.
• For the functionalization of heterocycles and complex molecular scaffolds in medicinal chemistry.

Basic Information

Product Name	5-Chloro-2-Methoxyphenylmagnesium Bromide, 0.50M In 2-Methyltetrahydrofuran
CAS No.	419535-75-4
Molecular Formula	C7H6BrClMgO
Molecular Weight	245.78 g/mol (for C7H6BrClMgO)
Synonyms	5-Chloro-2-methoxyphenylmagnesium bromide; (5-Chloro-2-methoxyphenyl)magnesium bromide; 2-Methoxy-5-chlorophenylmagnesium bromide; Grignard Reagent (5-Chloro-2-methoxyphenyl)magnesium bromide; 5-Chloro-o-anisylmagnesium bromide; 0.5M 5-Chloro-2-methoxyphenylmagnesium bromide in 2-MeTHF; Magnesium, bromo(5-chloro-2-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methoxyphenylmagnesium Bromide solution is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm concentration, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing titration results and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its hygroscopic and highly volatile nature, the container must be kept sealed and handled under anhydrous conditions. Recommended storage temperature is 2-8°C for extended stability, although short-term storage at 15-25°C is acceptable. Keep away from moisture, heat, and incompatible materials such as acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in 2-Methyltetrahydrofuran (2-MeTHF)
Assay (by Titration)	0.45 - 0.55 M
Identification (IR)	Conforms to structure
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.