Description

4-iso-Propylbenzylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to act as a powerful nucleophile and strong base, enabling the efficient introduction of the 4-isopropylbenzyl group into target molecules. This compound is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing lipophilic aromatic moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require specific substituted benzyl structures.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Fine Chemical and Specialty Material Production: Employed in the creation of liquid crystals, organic semiconductors, and other performance materials.
• Academic and R&D Laboratories: A fundamental tool for methodological development and exploratory synthesis in organic chemistry.
• Cross-Coupling Reactions: Functions as an effective coupling partner in reactions such as Kumada coupling for constructing biaryl systems.

Basic Information

Item	Detail
Product Name	4-iso-Propylbenzylmagnesium Chloride
CAS No.	405506-94-7
Molecular Formula	C10H13ClMg
Molecular Weight	192.96 g/mol
Synonyms	4-Isopropylbenzylmagnesium Chloride; (4-Isopropylphenyl)methylmagnesium Chloride; p-Cumenylmethylmagnesium Chloride; 1-Chloromagnesio-4-(propan-2-yl)benzene; 4-(1-Methylethyl)benzylmagnesium Chloride; Grignard Reagent (4-Isopropylbenzyl); Magnesium, chloromethyl(4-isopropylphenyl)-
EINECS	Contact for details

Quality Control

Our 4-iso-Propylbenzylmagnesium Chloride is produced under stringent quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity, consistency, and reliable performance in sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with detailed specifications for concentration, titration assay, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. It is typically supplied and stored as a solution in tetrahydrofuran (THF) or diethyl ether at recommended temperatures. Avoid exposure to air, moisture, and incompatible materials such as protic solvents, acids, and oxidizers.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF)	0.5 M - 2.0 M (Customizable)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.