Description

4-tert-Butyl-2,6-Dimethylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to introduce the sterically hindered 4-tert-butyl-2,6-dimethylphenyl group into target molecules, a key step in constructing advanced intermediates for pharmaceuticals and specialty chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the production of active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial building block for constructing complex drug molecules, particularly those requiring sterically hindered aromatic systems.
• Agrochemical Active Ingredient Development: Used in the synthesis of advanced herbicides, fungicides, and pesticides where the specific aryl group imparts desired biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis and transition metal complexes.
• Material Science and Polymer Chemistry: Employed to create novel monomers or functionalize polymers, leading to materials with tailored thermal or mechanical properties.
• Fine Chemical and Specialty Chemical Production: Integral in the multi-step synthesis of dyes, flavors, fragrances, and electronic chemicals.
• Academic and Industrial Research: A valuable tool for methodological development and exploring new reaction pathways in organic chemistry laboratories.

Basic Information

Product Name	4-tert-Butyl-2,6-Dimethylphenylmagnesium Bromide
CAS No.	400656-18-0
Molecular Formula	C12H17BrMg
Molecular Weight	265.47 g/mol
Synonyms	2,6-Dimethyl-4-(tert-butyl)phenylmagnesium bromide; (4-tert-Butyl-2,6-dimethylphenyl)magnesium bromide; 1-Bromo-4-tert-butyl-2,6-dimethylmagnesiumbenzene; Grignard reagent of 1-bromo-4-tert-butyl-2,6-dimethylbenzene; 4-(tert-Butyl)-2,6-dimethylphenylmagnesium bromide; 4-tert-Butyl-2,6-xylenylmagnesium bromide; Magnesium, bromo[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]-
EINECS	Contact for details

Quality Control

Every batch of 4-tert-Butyl-2,6-Dimethylphenylmagnesium Bromide is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (by titration), concentration in solution, and residual solvent content. Our quality assurance protocols are designed to meet the stringent requirements of cGMP and ISO standards for pharmaceutical and fine chemical applications, ensuring batch-to-batch consistency and reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, easily oxidized, and hygroscopic. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For optimal stability, maintain at recommended low temperatures (typically between 2°C to 8°C) and keep away from moisture, heat, and incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Colorless to light yellow or brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.