Description

Poly-N(6)-Methyladenylic Acid is a synthetic, chemically modified polynucleotide analog of polyadenylic acid. This specialized biochemical is a critical tool in molecular biology and biochemistry research, particularly for studying RNA processing, polyadenylation, and enzyme-substrate interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers requiring high-purity, well-characterized nucleotide polymers for their experimental and developmental work.

Application

• Enzymology Studies: Used as a substrate or inhibitor for enzymes like poly(A) polymerase, polynucleotide phosphorylase, and other nucleotidyltransferases to investigate reaction mechanisms and kinetics.
• Molecular Biology Research: Serves as a model compound for studying RNA polyadenylation signals, tail length regulation, and mRNA stability in in vitro systems.
• Diagnostic Reagent Development: Employed in the formulation and calibration of diagnostic assays that detect or quantify polyadenylate-binding proteins or specific nucleases.
• Biochemical Standard: Acts as a reference standard in chromatographic (HPLC, SEC) and spectroscopic analyses for quality control of related nucleotide materials.
• Nucleic Acid Chemistry: Provides a backbone for further chemical modifications or conjugation, enabling the creation of novel probes and tools for biotechnology applications.

Basic Information

Product Name	Poly-N(6)-Methyladenylic Acid
CAS No.	49717-66-0
Molecular Formula	(C11H14N5O6P)n
Molecular Weight	343.23 (monomer) * n
Synonyms	Poly(6-methyladenylic acid); Poly(N6-methyladenylic acid); N6-Methylpolyadenylic Acid; Poly(m6A); Poly(N6-methyladenylate); 6-Methylpoly(A); Poly(6-methyladenylate); Poly(N6-methyladenylate) sodium salt
EINECS	Contact for details

Quality Control

Our Poly-N(6)-Methyladenylic Acid is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as absorbance ratios, chain length distribution, and enzymatic activity. We adhere to rigorous in-house quality standards to meet the exacting requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (UV-Vis)	Characteristic spectrum of methylated adenylate
A260/A280 Ratio	≥ 2.0
Assay (HPLC)	≥ 95% (Polymer Content)
Solubility	Soluble in aqueous buffers, TE buffer
Biological Activity	Susceptible to specific nucleases (e.g., S1 Nuclease)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.