Description

Polyinosinic-Polycytidylic Acid Sodium Salt is a synthetic double-stranded RNA (dsRNA) polymer, widely recognized for its potent immunostimulatory properties. This compound is a critical reagent in biomedical research and pharmaceutical development, primarily used to mimic viral infection and stimulate innate immune responses. It is essential for researchers and manufacturers in the fields of virology, immunology, vaccine adjuvants, and oncology drug discovery.

Application

• Immunological Research: As a toll-like receptor 3 (TLR3) agonist to study innate immune signaling pathways and interferon production.
• Vaccine Adjuvant Development: Investigated for use in antiviral and anticancer vaccines to enhance immune response efficacy.
• Oncology Studies: Used in cancer research to induce apoptosis and study dsRNA-mediated anti-tumor effects.
• Virology: Serves as a viral dsRNA analog to stimulate cellular antiviral states and study host-pathogen interactions.
• Cell Culture & In Vivo Models: Applied to induce poly I:C-mediated effects in various biological models.
• Pharmaceutical Intermediates: Acts as a key starting material or active component in the synthesis of advanced therapeutic agents.

Basic Information

Product Name	Polyinosinic-Polycytidylic Acid Sodium Salt
CAS No.	42424-50-0
Molecular Formula	(C10H11N4Na2O8P)n • (C9H10N3Na2O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly I:C Sodium Salt; Polyinosinic acid • polycytidylic acid sodium salt; Poly I-C Sodium Salt; Polynosinic-Polycytidylic Acid Sodium; Polyriboinosinic-polyribocytidylic acid sodium; Poly(rI).Poly(rC) Sodium Salt; TLR3 Agonist (Poly I:C); dsRNA Sodium Salt
EINECS	Contact for details

Quality Control

Our Polyinosinic-Polycytidylic Acid Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity. Certificates of Analysis (COA) detailing specifications such as absorbance ratios (A250/A260, A280/A260), endotoxin levels, and bioburden are provided to support research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms
Absorbance Ratio (A250/A260)	0.80 - 0.95
Absorbance Ratio (A280/A260)	0.40 - 0.55
Assay (HPLC)	≥ 95% (Poly I:C Content)
Endotoxin	< 10 EU/mg
Bioburden	< 100 CFU/g
Solubility	Soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.