Description

Poly-2-Thiouridylic Acid is a chemically modified polynucleotide where the uracil base is substituted with a 2-thiouracil moiety. This structural modification is critical for its role in biochemical research, particularly in the study of nucleic acid structure, stability, and function. It is an essential tool for researchers in pharmaceutical development, molecular biology, and diagnostic assay design, where precise control over RNA interactions and stability is required.

Application

• Biochemical Research: Used as a model compound to study the effects of thiolation on RNA structure, thermal stability, and hybridization properties.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of oligonucleotide-based therapeutics, including antisense drugs and siRNA.
• Diagnostic Assays: Employed in the design and calibration of diagnostic probes and sensors that utilize modified nucleic acids for enhanced specificity.
• Enzymology Studies: Acts as a substrate or inhibitor for enzymes involved in RNA metabolism, such as nucleases and polymerases, to investigate mechanistic pathways.
• Material Science: Investigated for potential use in creating functional biopolymers or nanomaterials with unique electronic or binding properties.

Basic Information

Product Name	Poly-2-Thiouridylic Acid
CAS No.	41686-01-5
Molecular Formula	(C9H11N2O8PS)n
Molecular Weight	Contact for details
Synonyms	Poly(2-thiouridylic acid); 2-Thio-Uridylic Acid Polymer; Poly(2-thiouridine 5'-phosphate); 2-Thiouridine Polynucleotide; Poly(2-thioU); Poly(2-thiouridylate); Poly(U2S); 2-Thio-poly(U)
EINECS	Contact for details

Quality Control

Our Poly-2-Thiouridylic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, UV-Vis spectroscopy for concentration, and gel electrophoresis for chain length distribution. We provide full traceability and Certificates of Analysis (COA) to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (UV)	Complies
Purity (HPLC)	≥ 95%
Absorbance Ratio (A260/A280)	1.8 - 2.0
Moisture Content (KF)	≤ 5.0 %
Endotoxin	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.