Description

Phenylacetylenemagnesium Chloride is a highly reactive Grignard reagent, a cornerstone organometallic compound for advanced organic synthesis. Its primary value lies in its ability to act as a powerful nucleophile, enabling the efficient formation of new carbon-carbon bonds. This makes it an indispensable building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for constructing complex molecular architectures and introducing the versatile phenylacetylene moiety.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing active pharmaceutical ingredients (APIs), especially those containing alkyne or arylacetylene functional groups.
• Agrochemical Production: Used in the synthesis of advanced crop protection agents and herbicides that require specific acetylene-based structures.
• Material Science & Polymer Chemistry: Serves as a monomer or coupling agent in the development of conductive polymers, liquid crystals, and other advanced functional materials.
• Fine Chemical Manufacturing: Employed in the production of complex fragrance compounds, dyes, and other high-value specialty chemicals.
• Cross-Coupling Reactions: An essential partner in palladium-catalyzed reactions (e.g., Sonogashira, Negishi) for creating conjugated systems.
• Academic & R&D Laboratories: A fundamental tool for methodological development and exploratory synthesis in organic chemistry research.

Basic Information

Product Name	Phenylacetylenemagnesium Chloride
CAS No.	4890-63-5
Molecular Formula	C8H5ClMg
Molecular Weight	160.88 g/mol
Synonyms	Magnesium, chlorophenylacetylene-; Phenylacetylene magnesium chloride; (Phenylethynyl)magnesium chloride; Ethynylbenzene magnesium chloride; Grignard reagent, phenylacetylenemagnesium chloride; C6H5C≡CMgCl; Phenylethynylmagnesium chloride solution
EINECS	Contact for details

Quality Control

Our Phenylacetylenemagnesium Chloride is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration for active Grignard content and spectroscopic analysis, to ensure consistency and high reactivity. Certificates of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or diethyl ether), and other critical parameters are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This product is both hygroscopic (moisture-sensitive) and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability and potency. Handle and transfer only under anhydrous, inert conditions using proper techniques to exclude air and moisture.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown solution
Concentration	Typically 0.5 M in THF or Et2O (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.