Description

Pth-Methionine CAS NO 4370-90-5 is a protected derivative of the essential amino acid methionine, where the amino group is shielded by a phthaloyl (Pth) group. This modification is critical for enabling selective peptide synthesis and protecting sensitive functional groups during complex organic reactions. It is an indispensable building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptides, APIs, and fine chemicals.

Application

• Peptide Synthesis: Serves as a key protected amino acid intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Biochemical Research: Employed as a standard or reagent in proteomics, enzymology, and metabolic pathway studies.
• Fine Chemical Production: Acts as a chiral building block for the synthesis of complex organic molecules and specialty chemicals.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in laboratories.

Basic Information

Product Name	Pth-Methionine
CAS No.	4370-90-5
Molecular Formula	C₁₄H₁₅NO₄S
Molecular Weight	293.34 g/mol
Synonyms	N-Phthaloylmethionine; N-(Tert-Butoxycarbonyl)-L-methionine N-Carboxy Anhydride (related precursor); Phthalimidomethionine; 2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)]-4-(methylthio)butanoic acid; L-Methionine, N-phthaloyl-; N-Phthaloyl-L-methionine; Protected Methionine; PTH-Met
EINECS	Contact for details

Quality Control

Our Pth-Methionine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.