Description

Triprolidine is a potent, selective histamine H1-receptor antagonist belonging to the alkylamine class of first-generation antihistamines. Its primary value lies in its efficacy for managing allergic conditions, offering rapid onset of action. This active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry developing antihistamine formulations. It is also utilized in research settings for studying histamine pathways and receptor interactions.

Application

• Pharmaceutical API: Core active ingredient in prescription and over-the-counter (OTC) antihistamine medications for allergy relief.
• Allergy & Cold Formulations: Used in tablets, syrups, and combination products to treat symptoms of hay fever, allergic rhinitis, urticaria, and the common cold.
• Veterinary Pharmaceuticals: Incorporated into animal health products for managing allergic reactions in livestock and companion animals.
• Biochemical Research: A standard compound for in vitro and in vivo studies targeting the histamine H1 receptor in pharmacological and immunological research.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Intermediate Synthesis: Potential use as a chemical intermediate in the synthesis of more complex therapeutic molecules.

Basic Information

Product Name	Triprolidine
CAS No.	486-12-4
Molecular Formula	C19H22N2
Molecular Weight	278.40 g/mol
Synonyms	(E)-1-(4-Methylphenyl)-1-(2-pyridinyl)-3-pyrrolidin-1-yl-prop-1-ene; (±)-Triprolidine; trans-Triprolidine; Triprolidine base; 2-[1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]pyridine; Actidil; Actidilon; Pro-Actidil
EINECS	207-625-2

Quality Control

Our Triprolidine is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing parameters such as assay, related substances, and residual solvents. We support compliance with major pharmacopoeial standards (e.g., USP, EP) and regulatory frameworks including ICH Q7 and REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.