Description

Chlorphenamine Maleate CAS NO 113-92-8 is a potent, first-generation alkylamine antihistamine widely used in its salt form for enhanced stability and bioavailability. This compound is critical for its reliable antagonism of the H1 receptor, effectively managing allergic responses. It is an essential active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical industry, particularly for producing antihistamine tablets, syrups, and combination cold/flu medications.

Application

• Primary Active Pharmaceutical Ingredient (API) in antihistamine tablets and capsules.
• Key component in liquid formulations such as cough syrups and pediatric elixirs.
• Used in over-the-counter (OTC) and prescription combination drugs for cold and flu symptoms.
• Manufacturing of anti-allergy injections for rapid relief in clinical settings.
• Research and development of novel drug delivery systems for improved efficacy.
• Reference standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Chlorphenamine Maleate
CAS No.	113-92-8
Molecular Formula	C20H23ClN2O4
Molecular Weight	390.86 g/mol
Synonyms	Chlorpheniramine Maleate; Chlorprophenpyridamine Maleate; 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine maleate; Piriton; Aller-Chlor; Chlor-Trimeton; Teldrin; Histafen; Phenetron; C-Mall
EINECS	204-036-9

Quality Control

Our Chlorphenamine Maleate is manufactured under strict quality management systems. It meets or exceeds relevant pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.