Description

Meclizine Dihydrochloride is a high-purity pharmaceutical active ingredient, a dihydrochloride salt form of the well-known antihistamine. This compound is critical for ensuring the efficacy and stability of finished pharmaceutical formulations. It is primarily required by manufacturers in the pharmaceutical and life sciences industries for the development and production of antiemetic and antivertigo medications.

Application

• Active Pharmaceutical Ingredient (API) in antiemetic tablet and capsule formulations.
• Key intermediate in the synthesis of specialized pharmaceutical products targeting motion sickness.
• Reference standard in analytical laboratories for quality control and method development (HPLC, GC).
• Raw material for clinical research and preclinical studies in neurology and vestibular disorders.
• Component in veterinary pharmaceutical preparations for treating nausea in animals.

Basic Information

Product Name	Meclizine Dihydrochloride
CAS No.	1104-22-9
Molecular Formula	C25H27ClN2·2HCl
Molecular Weight	463.87 g/mol
Synonyms	Meclizine HCl; Meclozine Dihydrochloride; 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride; Postafen; Bonine; Antivert; Histametizyne Dihydrochloride; Chiclida
EINECS	214-163-6

Quality Control

Our Meclizine Dihydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant pharmacopeial standards, and the product is suitable for use in GMP-regulated environments. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The material is hygroscopic; keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.