Description

Dexbrompheniramine CAS NO 132-21-8 is the pharmacologically active dextrorotatory enantiomer of brompheniramine, a first-generation alkylamine antihistamine. This high-purity active pharmaceutical ingredient (API) is critical for developing targeted therapeutic formulations with enhanced efficacy and a potentially improved side-effect profile. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of prescription and over-the-counter (OTC) allergy, cold, and cough medications.

Application

• Pharmaceutical API: Core active ingredient in solid oral dosage forms (tablets, capsules) and liquid formulations (syrups, elixirs) for allergy relief.
• Antihistamine Preparations: Used in mono-therapy or combination cold/flu products to treat symptoms of allergic rhinitis, hay fever, and the common cold.
• Veterinary Pharmaceuticals: Incorporated into medications for managing allergic conditions in companion animals.
• Clinical Research: Serves as a reference standard and raw material for pharmacokinetic, pharmacodynamic, and new formulation studies.
• Controlled-Release Formulations: A key component in the development of extended-release allergy medications for prolonged symptom control.

Basic Information

Product Name	Dexbrompheniramine
CAS No.	132-21-8
Molecular Formula	C16H19BrN2
Molecular Weight	319.24 g/mol
Synonyms	(+)-Brompheniramine; D-Brompheniramine; Dexbrompheniramine Maleate (salt form); Drixoral (common brand name); 2-[p-Bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine; (+)-3-(4-Bromophenyl)-N,N-dimethyl-3-pyrid-2-yl-propan-1-amine; Dexchlorpheniramine related compound (isomer)
EINECS	205-056-5

Quality Control

Our Dexbrompheniramine is manufactured and tested under a strict quality management system. It is produced to meet exacting standards for pharmaceutical use, with specifications typically aligned with major pharmacopoeial guidelines. Comprehensive testing includes identity, purity, assay, and control of specific impurities and residual solvents. A Certificate of Analysis (COA) documenting all test results is provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+30.0° to +40.0° (c=1 in methanol)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.