Description

Chlorcyclizine Dihydrochloride is a high-purity pharmaceutical-grade antihistamine compound, essential for research and development in the life sciences sector. Its primary value lies in its role as a key intermediate and reference standard for developing and validating therapeutic agents targeting histamine H1 receptors. This product is critically needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in drug discovery, pharmacology studies, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antihistamine drug candidates and related medicinal compounds.
• Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories (HPLC, GC, LC-MS) to ensure product purity and regulatory compliance.
• Pharmacological Research: A vital tool for in vitro and in vivo studies investigating histamine receptor antagonism, allergy mechanisms, and central nervous system (CNS) activity.
• Active Pharmaceutical Ingredient (API) Development: Employed in the formulation development and stability testing of potential new therapeutic entities.
• Biochemical Assay Development: Utilized as a ligand in competitive binding assays and high-throughput screening (HTS) platforms to identify new drug leads.

Basic Information

Product Name	Chlorcyclizine Dihydrochloride
CAS No.	129-71-5
Molecular Formula	C18H21ClN2·2HCl
Molecular Weight	369.75 g/mol
Synonyms	1-(4-Chlorobenzhydryl)-4-methylpiperazine Dihydrochloride; Chlorcyclizine HCl; Histachlorazine; Diparalene; Perazil; Chlorcyclizine Hydrochloride; 1-[(4-Chlorophenyl)-phenylmethyl]-4-methylpiperazine Dihydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-methylpiperazine Dihydrochloride
EINECS	204-951-2

Quality Control

Our Chlorcyclizine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.