Description

Diphenhydramine Hydrochloride is a well-established pharmaceutical active ingredient and versatile chemical intermediate of significant commercial importance. Its primary value lies in its potent antihistaminic and anticholinergic properties, making it a critical component for manufacturers of pharmaceutical formulations. This compound is essential for producers in the pharmaceutical, veterinary medicine, and research & development sectors seeking a reliable, high-quality active pharmaceutical ingredient (API).

Application

• Pharmaceutical API: Primary active ingredient in over-the-counter (OTC) and prescription medications for allergy relief, sleep aids, motion sickness prevention, and cough suppression.
• Veterinary Pharmaceuticals: Used in formulations for treating allergic reactions, motion sickness, and as a sedative for animals.
• Chemical Synthesis: Serves as a key intermediate or starting material for the synthesis of more complex pharmaceutical molecules and derivatives.
• Research & Development: Utilized in biochemical and pharmacological research as a reference standard and for studying histamine H1-receptor antagonists.
• Finished Dosage Forms: Incorporated into various final product forms including tablets, capsules, oral solutions, creams, and injectables.

Basic Information

Product Name	Diphenhydramine Hydrochloride
CAS No.	147-24-0
Molecular Formula	C17H21NO·HCl
Molecular Weight	291.82 g/mol
Synonyms	2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride; Benadryl (trade name); Dimedrol; Diphenhydramine HCl; 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride; Allergy Relief Active; DPH; Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride
EINECS	205-687-2

Quality Control

Our Diphenhydramine Hydrochloride is manufactured under strict quality management systems, with grades available to meet various pharmacopoeial standards including USP and EP. Each batch undergoes comprehensive analytical testing to ensure identity, purity, strength, and composition. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to prevent absorption of atmospheric moisture and degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Chloride)	Positive reaction
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
pH (5% solution)	4.0 - 6.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.