Description

Phenyltoloxamine Citrate is the citrate salt form of an ethanolamine-derivative antihistamine, offering enhanced stability and solubility for pharmaceutical formulations. This compound is valued for its reliable antagonistic activity against the H1 histamine receptor, making it a critical active pharmaceutical ingredient (API) for specific therapeutic applications. It is primarily required by pharmaceutical manufacturers and research institutions developing formulations for allergy relief, cough suppression, and sleep aids.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter (OTC) antihistamine medications.
• Allergy & Cold Formulations: Key component in multi-symptom relief products targeting allergic rhinitis, hay fever, and common cold symptoms.
• Antitussive Preparations: Utilized in cough syrup and lozenge formulations for its cough-suppressant (antitussive) properties.
• Sedative-Hypnotic Aids: Incorporated into sleep aid products due to its pronounced sedative side effect.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for managing allergic reactions in animals.
• Research & Development: Serves as a reference standard and building block in pharmacological research and new drug development.

Basic Information

Product Name	Phenyltoloxamine Citrate
CAS No.	1176-08-5
Molecular Formula	C17H21NO • C6H8O7
Molecular Weight	447.47 g/mol
Synonyms	Phenyltoloxamine hydrogen citrate; 2-[(2-Benzylphenoxy)methyl]-N,N-dimethylethanamine citrate; Citrate salt of N,N-Dimethyl-2-[2-(phenylmethyl)phenoxy]ethanamine; Phenyltoloxamine dihydrogen citrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, compd. with N,N-dimethyl-2-[2-(phenylmethyl)phenoxy]ethanamine (1:1); Phenyltoloxamine Citrate Salt; Phenyltoloxamine Citrate (USP); Phenyltoloxamine Citrate (Ph. Eur.)
EINECS	214-598-9

Quality Control

Our Phenyltoloxamine Citrate is manufactured under strict quality management systems, with specifications designed to meet or exceed major pharmacopoeial standards such as USP and Ph. Eur. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting full compliance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.