Description

Pyrilamine Maleate CAS NO 59-33-6 is a high-purity pharmaceutical-grade antihistamine compound, specifically the maleate salt of pyrilamine. This active pharmaceutical ingredient (API) is critical for its potent H1-receptor antagonistic properties, which effectively inhibit histamine-mediated allergic responses. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of anti-allergy medications, topical preparations, and in advanced pharmacological research.

Application

• Pharmaceutical API: Core active ingredient in prescription and over-the-counter (OTC) antihistamine tablets, capsules, and syrups for treating allergic rhinitis, hay fever, and urticaria.
• Topical Formulations: Used in creams, ointments, and gels designed to relieve itching and inflammation associated with insect bites, skin allergies, and minor dermatological conditions.
• Veterinary Medicine: Incorporated into animal health products for managing allergic reactions and pruritus in companion animals and livestock.
• Combination Drug Therapy: Employed in multi-active pharmaceutical preparations, often combined with analgesics, decongestants, or expectorants for cold and flu symptom relief.
• Biochemical Research: Serves as a reference standard and a key reagent in pharmacological studies investigating histamine pathways, receptor binding assays, and the development of new therapeutic agents.
• Analytical Standard: Used as a certified reference material (CRM) in quality control laboratories for HPLC, UV, and other analytical method development and validation.

Basic Information

Product Name	Pyrilamine Maleate
CAS No.	59-33-6
Molecular Formula	C17H23N3O ∙ C4H4O4
Molecular Weight	401.45 g/mol
Synonyms	Mepyramine Maleate; Pyrilamine Maleate Salt; Anthisan; N-(4-Methoxybenzyl)-N',N'-dimethyl-N-2-pyridylethylenediamine Maleate; 2-[(2-Dimethylaminoethyl)(4-methoxybenzyl)amino]pyridine maleate; Histadyl; Paraminyl; Pyra-Maleate; Pyralgin
EINECS	200-418-5

Quality Control

Our Pyrilamine Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmaceutical-grade specifications, including identity, purity, and impurity profile. We provide full traceability and support regulatory submissions. A detailed Certificate of Analysis (COA) is supplied with every shipment, confirming compliance with in-house specifications aligned with major pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Melting Point	98°C - 102°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.