Description

4-Trifluoromethylphenylmagnesiumbromide CAS NO 402-51-7 is a versatile organometallic reagent, specifically a Grignard reagent, essential for introducing the 4-(trifluoromethyl)phenyl group into molecular frameworks. This compound is highly valued for its role in creating carbon-carbon bonds, a fundamental step in synthesizing complex organic molecules with tailored properties. It is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require precise functionalization to develop new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl moiety improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer & Specialty Chemicals: Employed to incorporate fluorinated phenyl groups into polymers and specialty chemicals to modify thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: A crucial reactant in palladium-catalyzed cross-coupling reactions (e.g., Kumada coupling) for constructing biaryl structures.
• Academic & R&D Laboratories: Fundamental tool for synthetic organic chemists in universities and corporate R&D for exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	4-Trifluoromethylphenylmagnesiumbromide
CAS No.	402-51-7
Molecular Formula	C7H4BrF3Mg
Molecular Weight	249.31 g/mol
Synonyms	(4-(Trifluoromethyl)phenyl)magnesium bromide; 4-(Trifluoromethyl)phenylmagnesium bromide; p-Trifluoromethylphenylmagnesium bromide; 1-Bromo-4-(trifluoromethyl)benzene magnesium; Magnesium, bromo[4-(trifluoromethyl)phenyl]-; Grignard Reagent (4-CF3C6H4MgBr); α,α,α-Trifluoro-p-tolylmagnesium bromide
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylphenylmagnesiumbromide is produced and handled under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for your synthetic processes. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. This material is easily oxidized and must be stored under an inert atmosphere (argon or nitrogen). Recommended storage temperature is 2-8°C. Keep the container tightly sealed in a dry, well-ventilated place. Isolate from incompatible materials such as strong acids, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Solvent Content (GC)	Balance

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.