Description

(3-(Trifluoromethyl)Phenyl)Magnesium Bromide, 0.25 M In Thf is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the introduction of the 3-(trifluoromethyl)phenyl group. This compound matters for its ability to form new carbon-carbon bonds, a fundamental transformation in constructing complex molecules, particularly in the development of pharmaceuticals and agrochemicals. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity building blocks for their synthetic workflows.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing active pharmaceutical ingredients (APIs), especially those containing the trifluoromethyl group known for enhancing metabolic stability and lipophilicity.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides where the trifluoromethyl moiety improves biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Advanced Material Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers where the phenyl-trifluoromethyl unit modifies electronic and physical properties.
• Fine Chemical Production: Facilitates the production of complex fragrance and flavor molecules, as well as dyes and pigments.
• Academic and Industrial R&D: A staple reagent in research laboratories for methodological development and exploratory synthesis of novel organic compounds.

Basic Information

Product Name	(3-(Trifluoromethyl)Phenyl)Magnesium Bromide, 0.25 M In Thf
CAS No.	402-26-6
Molecular Formula	C7H4BrF3Mg
Molecular Weight	249.31 g/mol
Synonyms	3-(Trifluoromethyl)phenylmagnesium bromide; m-(Trifluoromethyl)phenylmagnesium bromide; (3-Trifluoromethylphenyl)magnesium bromide; Magnesium, bromo[3-(trifluoromethyl)phenyl]-; 1-Bromo-3-(trifluoromethyl)benzene magnesium; Grignard Reagent (3-CF3-C6H4-MgBr); [3-(Trifluoromethyl)phenyl]magnesium bromide solution
EINECS	Contact for details

Quality Control

Our (3-(Trifluoromethyl)Phenyl)Magnesium Bromide solution is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm concentration, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing assay, titration results, and solvent content is provided with every shipment. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2°C to 8°C (refrigerated). The solution is highly volatile, easily oxidized, and reacts vigorously with moisture and protic solvents; ensure containers are securely sealed and handled under dry, inert conditions.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.25 M in Tetrahydrofuran (THF)
Assay (Titration)	0.23 M - 0.27 M
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.