Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt) is a high-purity, functionalized phospholipid derivative designed for advanced bioconjugation and drug delivery applications. This compound is critical for creating stable, targeted liposomal and nanoparticle formulations by providing a reactive maleimide group for covalent attachment to thiol-containing ligands, such as antibodies, peptides, or targeting moieties. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutics, including antibody-drug conjugates (ADCs), targeted liposomes, and diagnostic agents.

Application

• Liposome Functionalization: Key component for introducing targeting ligands onto the surface of liposomes for active drug targeting.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used in the construction of liposome-based ADCs or as a component in nanoparticle-antibody conjugates.
• Nanoparticle Surface Modification: Enables the site-specific conjugation of proteins, peptides, or other biomolecules to lipid-based nanoparticles (LNPs) and micelles.
• Biomembrane Research: A valuable tool for studying membrane dynamics, protein-lipid interactions, and cell surface engineering through controlled insertion of functional groups.
• Diagnostic Agent Development: Facilitates the creation of targeted contrast agents for molecular imaging (e.g., MRI, fluorescence) by linking imaging probes to delivery vehicles.
• Stimuli-Responsive Drug Delivery Systems: Can be incorporated into smart nanocarriers designed to release their payload in response to specific biological triggers.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt)
CAS No.	384835-50-1
Molecular Formula	C52H88N2O11PNa
Molecular Weight	970.23 g/mol
Synonyms	DPPE-MPB; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidophenyl)butyramide] sodium salt; Maleimide-DPPE; MPB-DPPE; DPPE-PE-Maleimide; N-[4-(p-Maleimidophenyl)butyryl]-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine sodium salt; 16:0 PE-MPB; Phospholipid-maleimide conjugate
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional integrity. We support development and cGMP manufacturing needs with rigorous analytical controls, including HPLC for purity and confirmation of maleimide group activity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to preserve the reactivity of the maleimide functional group. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Assay (Functional Maleimide)	≥90%
Solubility	Soluble in chloroform, DMSO, ethanol
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.