Description

1,3-Bis(o-Dimethoxytrityl)-2-(n-Fmoc-4-Aminobutyl)-1,3-Propanediol CAS NO 353754-96-8 is a sophisticated, bifunctional protected building block designed for solid-phase oligonucleotide synthesis. This compound is engineered to provide a versatile linker or branching point, enabling the controlled introduction of functional groups or labels into synthetic nucleic acid sequences. It is an essential high-purity intermediate for research and development laboratories focused on advanced oligonucleotide therapeutics, diagnostics, and functional genomics.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a specialized linker or branching monomer for constructing complex oligonucleotide architectures.
• Antisense & siRNA Therapeutics: Used in the synthesis of modified oligonucleotides for therapeutic applications requiring precise conjugation or labeling.
• Diagnostic Probe Development: Enables the site-specific incorporation of reporter molecules (e.g., fluorophores, quenchers) into DNA or RNA probes.
• Functional Genomics Research: A key reagent for creating custom oligonucleotide libraries and tools for gene expression analysis and editing.
• Peptide Nucleic Acid (PNA) Synthesis: Can be adapted for use in the synthesis of PNA oligomers, which are used as high-affinity nucleic acid analogs.
• Bioconjugation Chemistry: Provides a protected amine handle (via the Fmoc group) for subsequent coupling with other biomolecules or solid supports.

Basic Information

Product Name	1,3-Bis(o-Dimethoxytrityl)-2-(n-Fmoc-4-Aminobutyl)-1,3-Propanediol
CAS No.	353754-96-8
Molecular Formula	C67H68N2O9
Molecular Weight	1045.27 g/mol
Synonyms	1,3-Bis(DMT)-2-(Fmoc-aminobutyl)-1,3-propanediol; DMT-Fmoc-Aminobutyl-Glycerol Dimer; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butyl-1,3-bis[4,4'-dimethoxytrityloxy]propane; Fmoc-Aminobutyl-DMT-Glycerol Dimer; Oligonucleotide Synthesis Branching Monomer; Bifunctional DMT/Fmoc Protected Linker; 353754-96-8
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive oligonucleotide synthesis. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are provided with each batch to support your research and cGMP-compliant manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); desiccate upon opening and store under an inert atmosphere such as argon or nitrogen for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.