Description

N6-Benzoyl-2'-Deoxyadenosine is a chemically modified nucleoside derivative where a benzoyl group protects the N6 position of the adenine base. This compound is a critical building block in oligonucleotide synthesis, particularly for the automated solid-phase synthesis of DNA and RNA sequences. It is essential for researchers and manufacturers in the fields of molecular biology, diagnostics, and therapeutic development who require high-purity, reliable precursors for antisense oligonucleotides, primers, and probes.

Application

• Phosphoramidite Synthesis: Serves as the foundational precursor for the production of the corresponding 2'-deoxyadenosine phosphoramidite, a key reagent in automated DNA synthesizers.
• Oligonucleotide Manufacturing: Used in the solid-phase synthesis of DNA strands for research, diagnostic kits, and therapeutic applications like antisense drugs and siRNA.
• Antiviral & Anticancer Research: Acts as an intermediate in the development of nucleoside analog prodrugs targeting viral replication and cellular proliferation pathways.
• Bioconjugation & Labeling: The benzoyl protecting group allows for selective chemistry, enabling the creation of labeled nucleotides for detection and imaging studies.
• Process Development & Scale-Up: A vital raw material for process chemistry teams scaling up the production of active pharmaceutical ingredients (APIs) based on modified nucleic acids.

Basic Information

Product Name	N6-Benzoyl-2'-Deoxyadenosine
CAS No.	305808-19-9
Molecular Formula	C17H17N5O4
Molecular Weight	355.35 g/mol
Synonyms	2'-Deoxy-N6-benzoyladenosine; N6-Benzoyl-deoxyadenosine; Bz-dA; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-benzoylpurine; 2'-Deoxyadenosine, N6-benzoyl-; N-Bz-2'-deoxyadenosine; dA(Bz)
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-Deoxyadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment supports applications requiring compliance with cGMP, ICH Q7 guidelines, and other relevant pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.