Description

4-Chlorophenethylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its primary value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the synthesis of complex molecular architectures. This compound is particularly essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for introducing the 4-chlorophenethyl moiety into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: A critical building block for constructing active pharmaceutical ingredients (APIs), especially those containing aryl-alkyl ethers or substituted phenethylamine structures.
• Agrochemical Production: Used in the synthesis of herbicides, fungicides, and plant growth regulators that require the 4-chlorophenethyl functional group for bioactivity.
• Fine Chemical and Specialty Material Manufacturing: Employed in the production of liquid crystals, organic semiconductors, and advanced polymers where precise molecular structure is paramount.
• Academic and R&D Laboratories: Serves as a fundamental reagent for methodological development, catalysis research, and the exploration of new synthetic pathways in organic chemistry.
• Nucleophilic Addition Reactions: Primarily used for the addition to carbonyl compounds (aldehydes, ketones, esters) to form secondary or tertiary alcohols.
• Cross-Coupling Precursor: Can be transmetallated to form other organometallic species (e.g., zinc, copper reagents) for use in Negishi or Kumada cross-coupling reactions.

Basic Information

Product Name	4-Chlorophenethylmagnesium Bromide
CAS No.	36159-18-9
Molecular Formula	C8H8BrClMg
Molecular Weight	243.80 g/mol
Synonyms	2-(4-Chlorophenyl)ethylmagnesium Bromide; (4-Chlorophenethyl)magnesium Bromide; p-Chlorophenethylmagnesium Bromide; 4-Chloro-phenethylmagnesium Bromide; Magnesium, bromo[2-(4-chlorophenyl)ethyl]-; Grignard Reagent (4-Chlorophenethyl); Bromo(2-(4-chlorophenyl)ethyl)magnesium
EINECS	Contact for details

Quality Control

Our 4-Chlorophenethylmagnesium Bromide is produced under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and impurity profiling, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For extended stability, storage at 2-8°C is recommended. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Diethyl Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR/NMR)	Conforms to structure
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.