Description

11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate is a high-purity steroid derivative, specifically a methanesulfonate salt form of a key pregnadiene intermediate. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and advanced chemical synthesis laboratories focused on developing novel corticosteroid or other steroidal therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of corticosteroid drugs and other steroidal APIs.
• Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new steroid molecules.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for steroid manufacturing in a GMP environment.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory filing purposes.
• Biochemical Research: Utilized in studies investigating steroid hormone receptors, metabolism, and related biochemical pathways.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate
CAS No.	35410-28-7
Molecular Formula	C23H32O8S
Molecular Weight	468.56 g/mol
Synonyms	Prednisolone 21-Methanesulfonate; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-methanesulfonate; Prednisolone Mesylate; Prednisolone 21-(Methylsulfonate); NSC 113927; 21-Methanesulfonyloxyprednisolone; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-methanesulfonate
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.