Description

(9R,11S,14S,16R,17R)-6,6,9-Trifluoro-11,17-Dihydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-8,11,12,14,15,16-Hexahydro-7H-Cyclopenta[A]Phenanthren-3-One is a high-purity, complex fluorinated steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the production of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. Its unique trifluorinated and poly-hydroxylated structure makes it an essential building block for medicinal chemists and R&D teams in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel corticosteroid analogs and other potent steroid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to develop new drugs targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating steroid metabolism, receptor binding, and signal transduction pathways.
• Process Development: Utilized in the optimization of synthetic routes for the scalable production of fluorinated steroid compounds.

Basic Information

Product Name	(9R,11S,14S,16R,17R)-6,6,9-Trifluoro-11,17-Dihydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-8,11,12,14,15,16-Hexahydro-7H-Cyclopenta[A]Phenanthren-3-One
CAS No.	35135-68-3
Molecular Formula	C23H27F3O5
Molecular Weight	440.46 g/mol
Synonyms	6,6,9-Trifluoro-11β,17,21-Trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-Acetonide (misnomer); 6α,9α-Difluoro-16α-methylprednisolone 17,21-acetonide derivative; Fluorinated Corticosteroid Intermediate; 9R,11S,14S,16R,17R-Hexahydrocyclopenta[a]phenanthrenone derivative; 6,6,9-Trifluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethylhexahydrocyclopenta[a]phenanthren-3-one; 35135-68-3; Prednisolone trifluoro derivative
EINECS	Contact for details

Quality Control

Our (9R,11S,14S,16R,17R)-6,6,9-Trifluoro-11,17-Dihydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-8,11,12,14,15,16-Hexahydro-7H-Cyclopenta[A]Phenanthren-3-One is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de (by Chiral HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.