Description

Poly(G,I).Poly(C) CAS NO 34607-23-3 is a synthetic double-stranded RNA polymer composed of inosine-guanine and cytosine ribonucleotides. This compound serves as a critical molecular tool in immunology and virology research, primarily functioning as a potent inducer of interferon production. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who require reliable, high-purity reagents for studying antiviral responses, immune system modulation, and nucleic acid sensing pathways.

Application

• Immunological Research: Used as a standard ligand for Toll-like receptor 3 (TLR3) and other pattern recognition receptors to study innate immune activation.
• Antiviral Studies: Employed as a potent interferon inducer in cell culture models to investigate host defense mechanisms against viral infections.
• Vaccine Adjuvant Development: Investigated for its potential to enhance immune responses in novel vaccine formulations.
• Cell Signaling Pathways: A key reagent for elucidating intracellular signaling cascades triggered by double-stranded RNA, such as the RIG-I and MDA5 pathways.
• Quality Control in Biologics: Can be used in assay development to test the responsiveness of cell lines used in pharmaceutical testing.
• Oncology Research: Studied for its potential immunostimulatory effects in cancer immunotherapy models.

Basic Information

Product Name	Poly(G,I).Poly(C)
CAS No.	34607-23-3
Molecular Formula	(C10H12N5O7P · C9H12N3O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Polyinosinic-polycytidylic acid; Poly(I:C); Poly I:C; Polyinosinic acid-polycytidylic acid; Poly I-poly C; Inosinic acid-cytidylic acid copolymer; Polyriboinosinic-polyribocytidylic acid; pIC
EINECS	Contact for details

Quality Control

Our Poly(G,I).Poly(C) is manufactured under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including assessment of polynucleotide length, duplex integrity, endotoxin levels, and functional activity in cell-based assays. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance specifications is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize condensation and moisture uptake. For long-term stability, store as lyophilized powder. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Polymer Content)
Duplex Integrity	≥ 90% double-stranded
Endotoxin Level	< 0.1 EU/mg
Biological Activity	Induces interferon-alpha in human PBMCs at specified concentration
Solubility	Soluble in sterile, nuclease-free water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.