Description

Poly(A)-Poly(Da) CAS NO 32070-56-7 is a synthetic double-stranded polynucleotide complex formed from polyadenylic acid and poly(2,6-diaminopurine) ribonucleotide. This specialized nucleic acid analog is a critical research tool for studying nucleic acid interactions, enzyme mechanisms, and as a model substrate. It is primarily utilized by biochemical research laboratories, pharmaceutical R&D departments, and academic institutions engaged in molecular biology and enzymology studies.

Application

• Biochemical Research: As a model double-stranded RNA substrate for studying ribonuclease (RNase) activity, specificity, and inhibition kinetics.
• Enzymology Studies: Used to investigate the mechanisms of nucleic acid-processing enzymes, including helicases and polymerases.
• Nucleic Acid Hybridization: Serves as a control or competitor in hybridization experiments due to its defined base-pairing structure.
• Pharmaceutical Screening: Employed in high-throughput assays to identify and characterize novel antiviral or anticancer compounds that target RNA or RNA-protein complexes.
• Diagnostic Development: Potential use as a component in the development of diagnostic assays that rely on specific nucleic acid interactions.
• Biophysical Studies: Utilized in spectroscopic and calorimetric analyses to understand the thermodynamics and stability of nucleic acid duplexes.

Basic Information

Product Name	Poly(A)-Poly(Da) CAS NO 32070-56-7
CAS No.	32070-56-7
Molecular Formula	(C10H12N5O7P)n • (C10H13N7O6P)n
Molecular Weight	Variable (Polymer)
Synonyms	Polyadenylic acid - poly(2,6-diaminopurine ribonucleotide) complex; Poly(rA)-Poly(rDAP); Poly A - Poly Da; Polyadenylic-poly(2,6-diaminopurinic) acid; Poly(rA)•Poly(rDAP); Poly A • Poly Da; 2,6-Diaminopurine ribonucleotide polymer complex with adenylic acid polymer
EINECS	Contact for details

Quality Control

Our Poly(A)-Poly(Da) is produced and tested under stringent conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized for identity, purity, and duplex integrity. Certificates of Analysis (COA) detailing specific analytical results are available upon request, providing full traceability and supporting compliance with internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The material should be handled in a controlled environment to preserve its integrity.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV-Vis)	Characteristic absorption spectrum for polynucleotide complex
Duplex Integrity (Hypochromicity)	Conforms to standard
Solubility	Soluble in buffer solutions (e.g., Tris-EDTA, saline sodium citrate)
Purity (HPLC)	≥ 90% (Polymer peak)
Endotoxin (LAL)	< 10 EU/mg (if specified for biological use)
Storage	See Storage section

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.