Description

Phenylthiohydantoin-Proline (CAS NO 31364-82-6) is a specialized derivative of proline, a critical amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in advanced biochemical research and analytical chemistry, particularly for peptide sequencing and amino acid analysis. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and manufacturers of analytical reagents and standards.

Application

• Edman Degradation Reagent: A key intermediate or reference standard in the stepwise degradation of peptides and proteins for N-terminal amino acid sequencing.
• Analytical Reference Standard: Used for the calibration of HPLC, LC-MS, and other chromatographic systems in proteomics and metabolomics research.
• Biochemical Research: Serves as a building block or probe in studies investigating proline metabolism, protein structure, and post-translational modifications.
• Pharmaceutical Development: Employed in the synthesis and quality control of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Diagnostic Kit Manufacturing: A component in the production of kits for amino acid analysis and protein characterization.

Basic Information

Product Name	Phenylthiohydantoin-Proline
CAS No.	31364-82-6
Molecular Formula	C14H14N2O2S
Molecular Weight	274.34 g/mol
Synonyms	PTH-Proline; 3-Phenyl-2-thiohydantoin-Proline; 2-Thio-5-oxo-4-(1-carboxy-3-pyrrolidinyl)imidazolidine; L-Proline, 5-oxo-2-thioxo-4-(phenylmethyl)-1-imidazolidinyl-; Edman Degradation Product of Proline; PTH-Pro; 4-(Phenylmethyl)-2-thio-5-oxoimidazolidine-4-carboxylic acid (proline derivative)
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification, and residual solvent analysis, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.