Description

Polyadenosine is a synthetic polynucleotide composed of repeating adenosine monophosphate units, serving as a critical tool in molecular biology and biochemical research. Its consistent structure and predictable behavior make it an essential reagent for standardizing assays and calibrating equipment. This product is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical R&D departments for applications such as nucleic acid hybridization studies and enzyme activity testing.

Application

• Molecular Biology Research: Used as a standard or control in hybridization experiments, Northern blotting, and polymerase activity assays.
• Diagnostic Kit Development: Serves as a key component in the calibration and quality control of diagnostic assays targeting poly(A) sequences, such as in mRNA detection kits.
• Biochemical Studies: Employed as a substrate for studying enzymes like poly(A) polymerase, ribonucleases, and other nucleases to understand reaction kinetics and specificity.
• Vaccine & Therapeutic Research: Acts as a model compound or adjuvant component in immunological research, particularly in studies involving nucleic acid-based vaccines.
• Chromatography & Spectroscopy: Functions as a reference standard in HPLC, UV-Vis spectroscopy, and other analytical techniques for method development and validation.

Basic Information

Product Name	Polyadenosine
CAS No.	30143-02-3
Molecular Formula	(C10H12N5O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(A); Polyadenylic acid; Poly A; Polynucleotide (adenylic acid); Adenosine homopolymer; Poly rA; 5'-Adenylic acid homopolymer; Polyadenosine acid
EINECS	Contact for details

Quality Control

Our Polyadenosine is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including assessment of chain length distribution and quantification of impurities. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a dry environment to prevent absorption of water vapor. For short-term use, aliquots may be stored at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (UV)	Conforms (Characteristic absorption spectrum)
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Poly(A) content)
Chain Length (Average)	Contact for details (Specific grades available)
Absorbance Ratio (A260/A280)	1.8 - 2.0
Moisture Content (KF)	≤ 5.0 %
Endotoxin	< 10 EU/mg (Research Grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.