Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 11,21-Diacetate is a high-purity synthetic corticosteroid derivative, specifically the 11,21-diacetylated form of dexamethasone. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily required by advanced pharmaceutical manufacturers and research institutions for the synthesis of specialized steroid-based therapeutics and for use in biochemical research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent corticosteroid drugs, including dexamethasone and its derivatives.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of anti-inflammatory and immunosuppressive medications.
• Biomedical Research: Serves as a reference standard and a tool for studying glucocorticoid receptor activity, inflammation pathways, and immune response modulation.
• Veterinary Medicine: Employed in the development of anti-inflammatory treatments for animals.
• Process Development & Scale-Up: Utilized in R&D and pilot-scale production to optimize synthetic routes for steroid-based APIs.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 11,21-Diacetate
CAS No.	3949-26-6
Molecular Formula	C₂₆H₃₃FO₈
Molecular Weight	492.54 g/mol
Synonyms	Dexamethasone 21-Acetate; Dexamethasone Diacetate; 9α-Fluoro-16α-methylprednisolone 11β,21-diacetate; 11β,17,21-Trihydroxy-9α-fluoro-16α-methylpregna-1,4-diene-3,20-dione 11,21-diacetate; 9α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 11,21-diacetate; 16α-Methyl-9α-fluoroprednisolone 11β,21-diacetate; NSC-123011
EINECS	223-548-9

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 11,21-Diacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards suitable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically >98% by HPLC), related substances, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.