Description

N6-Methyladenosine 5'-Triphosphate (CAS NO 3130-39-0) is a crucial modified nucleotide triphosphate essential for RNA research and epigenetics. This compound serves as a direct substrate for studying and manipulating the m6A modification, a key regulator of gene expression and cellular function. It is primarily required by researchers in molecular biology, biochemistry, and pharmaceutical development for applications such as enzymatic synthesis, structural studies, and the development of diagnostic assays.

Application

• Enzymatic RNA Synthesis: Direct substrate for in vitro transcription to produce m6A-modified RNA for functional studies.
• Biochemical Assay Development: Used in activity assays for methyltransferases (writers), demethylases (erasers), and binding proteins (readers) involved in the m6A pathway.
• Epitranscriptomics Research: Critical for investigating the role of N6-methyladenosine in mRNA stability, splicing, translation, and cellular differentiation.
• Structural Biology: Crystallization and NMR studies to understand protein-RNA interactions specific to the m6A modification.
• Diagnostic & Therapeutic Discovery: Screening for inhibitors or modulators of m6A-related enzymes as potential drug targets in oncology and other diseases.
• Synthetic Biology: Engineering synthetic circuits or RNAs with tailored epigenetic marks for advanced biotechnological applications.

Basic Information

Product Name	N6-Methyladenosine 5'-Triphosphate
CAS No.	3130-39-0
Molecular Formula	C11H18N5O13P3
Molecular Weight	561.21 g/mol
Synonyms	m6ATP; N6-Methyl-ATP; 6-Methyladenosine-5'-triphosphate; N(6)-Methyladenosine 5'-triphosphate; 6-Methylaminopurine riboside triphosphate; Adenosine-5'-triphosphate, N6-methyl-; 6-Methyl-ATP; 5'-ATP, N6-methyl-
EINECS	Contact for details

Quality Control

Our N6-Methyladenosine 5'-Triphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive life science research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
Biological Activity	Suitable for enzyme reactions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.