Description

Thalidomide-o-Amido-Peg4-Propargyl is a specialized PROTAC linker and bioconjugation reagent designed for the synthesis of advanced pharmaceutical compounds. This bifunctional molecule is critical for researchers developing targeted protein degradation (TPD) therapies and antibody-drug conjugates (ADCs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on oncology, immunology, and other therapeutic areas requiring precise molecular engineering.

Application

• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a key linker component connecting E3 ligase ligands (e.g., Thalidomide derivatives) to target protein binders.
• Antibody-Drug Conjugate (ADC) Synthesis: Enables site-specific conjugation of cytotoxic payloads to antibodies via click chemistry-compatible propargyl and PEG4 spacer.
• Chemical Biology Research: Used as a tool compound for studying protein-protein interactions and intracellular degradation pathways.
• Bifunctional Reagent Production: Acts as a versatile building block for creating novel drug discovery libraries and molecular probes.
• Precision Medicine Platforms: Facilitates the development of next-generation targeted therapies with improved pharmacokinetic profiles.

Basic Information

Product Name	Thalidomide-o-Amido-Peg4-Propargyl
CAS No.	2411681-90-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thalidomide-PEG4-Propargyl; Thalidomide-O-amido-PEG4-alkyne; (S)-Thalidomide-PEG4-Propargyl; N-((1-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxapentadec-14-yn-1-amide; Thalidomide-based PROTAC linker; E3 Ligase Ligand-PEG4-Alkyne; Cereblon Ligand-PEG4-Propargyl
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Amido-Peg4-Propargyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of key intermediates used in pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.