Description

Protac Cdk2/9 Degrader-1 is a potent and selective heterobifunctional degrader molecule designed for targeted protein degradation research. This compound is a critical tool for investigating the roles of CDK2 and CDK9 in cellular processes and disease pathways, offering a mechanism distinct from traditional kinase inhibition. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on oncology, neurodegenerative diseases, and chemical biology for target validation and novel therapeutic discovery.

Application

• Target Validation Studies: Used to elucidate the specific biological functions and therapeutic potential of CDK2 and CDK9 in various disease models.
• Chemical Biology & PROTAC® Platform Development: Serves as a reference compound for designing and optimizing heterobifunctional degraders.
• Oncology Research: Applied in preclinical studies to assess the effects of CDK2/9 degradation on cancer cell proliferation, survival, and tumor growth.
• Neurodegenerative Disease Research: Investigated for its potential role in modulating pathological processes in conditions like Alzheimer's disease.
• Mechanism of Action (MoA) Studies: Employed to distinguish between kinase inhibition and protein degradation phenotypes.
• High-Content Screening (HCS): Used as a control or tool compound in cellular assays to identify novel degraders or synergistic agents.

Basic Information

Product Name	Protac Cdk2/9 Degrader-1
CAS No.	2408641-24-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC CDK2/9 Degrader-1; CDK2/9 Degrader-1; PROTAC® CDK2/9 Degrader; Heterobifunctional CDK2/9 Degrader; CDK2 and CDK9 Degrader; Degrader of CDK2 and CDK9; Targeted Protein Degrader for CDK2/9
EINECS	Contact for details

Quality Control

Every batch of Protac Cdk2/9 Degrader-1 is produced and analyzed under strict quality management protocols to ensure identity, purity, and batch-to-batch consistency suitable for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.