Description

Mal-Peg4-Vc-Pab-Dmea-Pnu-159682 is a sophisticated, multi-functional linker-payload conjugate designed for the development of targeted therapeutics. This compound is engineered to enable the precise delivery of potent cytotoxic agents to specific cells, thereby enhancing therapeutic efficacy while minimizing off-target effects. It is a critical component for researchers and developers in the fields of antibody-drug conjugate (ADC) development and targeted cancer therapy, where stability, controlled release, and linker technology are paramount.

Application

• Antibody-Drug Conjugate (ADC) Payload-Linker Assembly: Serves as a key building block for constructing next-generation ADCs, combining a protease-cleavable linker (Valine-Citrulline) with a self-immolative spacer (PAB) and a solubilizing PEG chain.
• Targeted Cancer Therapy R&D: Used in preclinical research to develop novel bioconjugates that selectively deliver chemotherapeutic agents to tumor cells expressing specific antigens.
• Prodrug Synthesis: Facilitates the creation of advanced prodrug systems where the active drug is released upon exposure to specific enzymatic environments, such as those found in tumor tissue.
• Bioconjugation and Chemical Biology: Employed as a versatile tool for site-specific labeling and modification of biomolecules (e.g., antibodies, proteins) for diagnostic and therapeutic applications.
• Pharmaceutical Intermediate: Acts as a high-value intermediate in the synthesis of complex clinical-stage ADC candidates and other targeted molecular entities.

Basic Information

Item	Details
Product Name	Mal-Peg4-Vc-Pab-Dmea-Pnu-159682
CAS No.	2259318-52-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Mal-PEG4-VC-PAB-DMEA-PNU-159682; Maleimide-PEG4-Val-Cit-PAB-DMEA-PNU-159682; MC-PEG4-VC-PAB-DMEA-PNU-159682; ADC Linker-Payload Conjugate for PNU-159682; Valine-Citrulline (VC) Cleavable Linker-PNU-159682 Conjugate; PNU-159682 ADC Intermediate; N-[2-[[2-[[2-[[2-[[(2,5-Dioxopyrrolidin-1-yl)oxy]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3-methylbutanoyl]-N-methyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide (Long IUPAC-like form)
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Vc-Pab-Dmea-Pnu-159682 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation work. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS for identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.