Description

Dreadd Agonist 21 Dihydrochloride is a potent and selective chemical tool compound designed for precise chemogenetic manipulation of neuronal activity. This high-purity research chemical is critical for advancing neuroscience and neuropharmacology studies, enabling targeted activation of DREADD (Designer Receptors Exclusively Activated by Designer Drugs) receptors in vivo and in vitro. It is an essential reagent for academic researchers, pharmaceutical R&D teams, and CROs focused on understanding neural circuits, behavior, and developing novel therapeutic strategies for neurological disorders.

Application

• Neuroscience Research: Selective activation of hM3Dq or other DREADD-expressing neurons in chemogenetic experiments to study circuit function and behavior.
• Neuropharmacology: Tool for validating drug targets and investigating signaling pathways in models of neurological and psychiatric diseases.
• Preclinical Animal Studies: Used in rodent models to establish causal links between specific neuronal populations and physiological or behavioral outcomes.
• Cell-Based Assays: Activation of engineered GPCRs in transfected cell lines for receptor characterization and high-throughput screening.
• Academic & Institutional R&D: Fundamental research in universities and institutes exploring neural connectivity, memory, and sensory processing.
• Biotech & Pharmaceutical Development: Supporting drug discovery pipelines for conditions like Parkinson's, epilepsy, anxiety, and addiction.

Basic Information

Product Name	Dreadd Agonist 21 Dihydrochloride
CAS No.	2250025-92-2
Molecular Formula	C23H30Cl2N4O3
Molecular Weight	505.42 g/mol
Synonyms	DCZ 21; C21; DREADD Agonist 21 diHCl; Compound 21 dihydrochloride; Chemogenetic Agonist 21; hM3Dq Agonist 21; Clozapine N-oxide (CNO) analog; N-[(2S,3R)-1-(3-Chlorophenyl)-2-(4-fluorophenyl)-4-oxoazetidin-3-yl]-1H-indazole-3-carboxamide dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Dreadd Agonist 21 Dihydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards expected for advanced research chemicals. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for HPLC purity, NMR identification, mass spectrometry, and residual solvent analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.