Description

N6-Benzoyl-9-(2'-Deoxy-5'-o-Dmt-2'-Fluoro-B-D-Arabinofuranosyl)Adenine 3'-Ce Phosphoramidite is a high-purity, protected phosphoramidite monomer specifically engineered for the solid-phase synthesis of oligonucleotides. This compound is critical for introducing a 2'-fluoro-arabinonucleic acid (2'-F-ANA) adenine modification, which enhances the nuclease resistance and binding affinity of therapeutic oligonucleotides. It is an essential raw material for research institutions and pharmaceutical companies developing advanced antisense, siRNA, and aptamer-based therapies.

Application

• Synthesis of 2'-Fluoro-Arabino Nucleic Acid (2'-F-ANA) Oligonucleotides: Key building block for creating oligonucleotides with improved metabolic stability and target affinity.
• Antisense Oligonucleotide (ASO) Development: Used in the manufacture of ASOs for therapeutic applications targeting genetic diseases.
• siRNA and miRNA Synthesis: Enables the incorporation of modified adenine bases to optimize siRNA and miRNA performance and pharmacokinetics.
• Aptamer Production: Facilitates the creation of stable, high-affinity nucleic acid aptamers for diagnostic and therapeutic use.
• Research Tool for Nucleic Acid Chemistry: Employed in academic and industrial R&D to study structure-activity relationships of modified oligonucleotides.
• Pre-clinical and Clinical-Grade Oligonucleotide Manufacturing: Serves as a critical starting material under GMP guidelines for producing therapeutic candidates.

Basic Information

Product Name	N6-Benzoyl-9-(2'-Deoxy-5'-o-Dmt-2'-Fluoro-B-D-Arabinofuranosyl)Adenine 3'-Ce Phosphoramidite
CAS No.	2248740-48-7
Molecular Formula	C53H55FN7O8P
Molecular Weight	968.02 g/mol
Synonyms	2'-F-ANA-A(Bz) Phosphoramidite; 5'-O-DMT-2'-deoxy-2'-fluoro-arabinoadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite (N6-Benzoyl); 2'-Deoxy-2'-fluoro-β-D-arabinofuranosyladenine N6-benzoyl-5'-O-DMT-3'-CE phosphoramidite; 2'-F-ArabinoA(Bz) CE Phosphoramidite; 9-[(2-Deoxy-2-fluoro-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)]-N6-benzoyladenine 3'-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]; 2'-F-ANA A(Bz) Phosphoramidite; 2'-Fluoro araA Phosphoramidite
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-9-(2'-Deoxy-5'-o-Dmt-2'-Fluoro-B-D-Arabinofuranosyl)Adenine 3'-Ce Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically ≥98% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We support development under GMP guidelines and can provide materials suitable for pre-clinical and clinical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Moisture Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.