Description

Dbco-Peg4-Acid CAS NO 2110448-99-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry and a terminal carboxylic acid for further conjugation via amide bond formation. This compound is essential for creating stable, well-defined bioconjugates without the need for cytotoxic copper catalysts, enabling the labeling and modification of biomolecules under mild, physiological conditions. It is a critical reagent for researchers and developers in bioconjugation, antibody-drug conjugate (ADC) development, proteomics, and advanced materials science.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key building block for constructing cleavable or non-cleavable linkers to connect cytotoxic payloads to monoclonal antibodies.
• Biomolecule Labeling & Functionalization: Enables site-specific labeling of proteins, peptides, oligonucleotides, and other azide-modified biomolecules for imaging, diagnostics, and therapeutic applications.
• Surface Modification & Material Science: Used to functionalize nanoparticles, hydrogels, biosensors, and other material surfaces with bioactive ligands or imaging probes.
• Proteomics & Chemical Biology: Facilitates the study of protein interactions, localization, and activity through bioorthogonal tagging strategies.
• Polymer & Dendrimer Synthesis: Acts as a versatile monomer or crosslinker for synthesizing functionalized PEG-based polymers and dendritic structures.
• Diagnostic Assay Development: Employed in the development of immunoassays, lateral flow tests, and other diagnostic platforms requiring stable biomolecule immobilization.

Basic Information

Product Name	Dbco-Peg4-Acid
CAS No.	2110448-99-0
Molecular Formula	C33H41N3O9
Molecular Weight	623.70 g/mol
Synonyms	DBCO-PEG4-COOH; DBCO-PEG4-Acid; Dibenzocyclooctyne-PEG4-Acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11-tetraoxatetradecan-14-yl) carbamate; DBCO-Amine-PEG4-Acid; DBCO-PEG4-NHS ester precursor; Azadibenzocyclooctyne-PEG4-Acid; SPAAC linker-PEG4-Acid
EINECS	Contact for details

Quality Control

Our Dbco-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.