Description

E3 Ligase Ligand-Linker Conjugates 5 is a sophisticated bifunctional chemical tool designed for the targeted degradation of proteins via the PROTAC (PROteolysis TArgeting Chimera) technology platform. This compound matters because it enables researchers to specifically eliminate disease-relevant proteins by hijacking the cell's natural ubiquitin-proteasome system, offering a powerful alternative to traditional inhibition. It is critically needed by pharmaceutical R&D teams and academic laboratories focused on drug discovery, particularly in oncology, neurodegenerative diseases, and other areas where undruggable targets are a challenge.

Application

• PROTAC Molecule Development: Serves as a key building block for constructing novel PROTAC degraders targeting specific proteins of interest.
• Chemical Biology Research: Used in mechanistic studies to validate E3 ligase engagement and understand ubiquitin-proteasome system dynamics.
• Targeted Protein Degradation (TPD) Platforms: Integral to high-throughput screening and optimization campaigns within TPD discovery pipelines.
• Oncology Drug Discovery: Enables the degradation of oncogenic drivers and resistance factors that are difficult to inhibit with small molecules.
• Neurological Disease Research: Applied in developing degraders for misfolded or aggregated proteins implicated in conditions like Alzheimer's and Parkinson's disease.
• Tool Compound Synthesis: Provides a versatile linker-ligand moiety for creating bespoke chemical probes to study specific biological pathways.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 5
CAS No.	2097971-11-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 5; E3 Ligand-Linker 5; Degrader Building Block 5; Ubiquitin Ligase Recruiter 5; Targeted Protein Degradation Tool 5; TPD Conjugate 5; Bifunctional Degradation Molecule Precursor
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 5 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes rigorous analytical characterization, including purity assessment by HPLC and structural confirmation by NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.